PathAR: Structure-First Autoregressive Synthesis of Multimodal Pathology Images

Data scarcity in multimodal pathology motivates unified generative models that synthesize modality-specific appearance while preserving anatomically coherent structure. Although modalities differ in appearance statistics, morphological structures such as cellular topology and tissue boundaries are largely preserved across acquisition protocols. However, existing methods often model these factors within a homogeneous token stream, implicitly coupling structure with appearance and weakening structural controllability under modality shifts. To address this, we propose pathology Autorgressive modeling (PathAR), a structure-first autoregressive synthesis framework that explicitly factorizes structure and appearance for modality-label-conditioned pathology generation.PathAR employs a dual vector quantization (Dual-VQ) tokenizer to decompose samples into mask-grounded structure and appearance tokens, and an interleaved autoregressive (IAR) transformer with asymmetric attention visibility to enforce structure-to-appearance dependence. PathAR stabilizes morphology under heterogeneous modality-specific appearances and enables spatially aligned image--mask pair generation. Extensive experiments show that PathAR improves structural consistency and modality fidelity over baselines, maintains sample diversity, supports downstream segmentation in data-scarce regimes, and demonstrates extensibility to finer-grained intra-modality organ-label variation.

AI-T2I: Aggregating-and-Isolating Cross-Attention to Diffusion Models for Text-to-Image Synthesis

Text-to-image synthesis has made significant progress, benefiting from the strong generative capabilities of diffusion models. However, these models struggle to achieve precise text-to-image alignment within cross-attention maps during the denoising process. Existing works primarily focus on inter-subject-token activations (i.e., cross-attention scores) overlap for different subjects, overlooking the intra-subject-token activations scattering issue for identical subjects. In this paper, we propose an Aggregating-and-Isolating cross-attention approach to diffusion models for Text-to-Image synthesis, dubbed AI-T2I. Technically, to address the scattering issue, we devise an aggregation loss to identify and consolidate the scattered intra-token activations, which implicitly helps mitigate the potential overlap issue. Upon that, an isolation loss is further introduced to push the inter-token activations apart, thus fulfilling precise text-to-image alignment. Extensive experiments on various benchmarks demonstrate the superiority of AI-T2I over the state-of-the-art works for text-to-image synthesis. Furthermore, our AI-T2I exhibits excellent generalization across other tasks, e.g., controllable layout generation and personalized generation. Our code is available at https://github.com/Hatter77/AI-T2I.

MARVEL: Universal Murray's Law-informed Vessel Tree Segmentation and Topology Estimation

Vascular circulation follows fundamental biophysical principles that optimize mass transport and metabolic energy expenditure, which can be effectively modeled by Murray's law. However, contemporary deep learning methods for vascular segmentation often neglect these biophysical constraints. This leads to physiologically implausible branching and misclassification vascular trees, rendering. These automated segmentation results are unreliable unreliable for downstream clinical tasks such as blood flow simulation or disease quantification. In this paper, we introduce MARVEL (Universal MurrAy's law-infoRmed Vessel sEgmentation and topoLogy estimation), a backbone-agnostic framework that integrates biophysical priors into vascular tree extraction. MARVEL combines per-pixel supervision with explicit radius predictions to enforce local bifurcation constraints derived from an empirical width-exponent mapping. We implement these constraints as differentiable regularizers during training to guide models toward physiologically consistent reconstructions. We evaluate MARVEL on eight public datasets across multiple vascular modalities and segmentation backbones. Results demonstrate MARVEL's superior performance in segmentation accuracy, topological consistency, and physiological plausibility. By converting segmented masks into graph-based hemodynamic simulations, we demonstrate that MARVEL preserves the subtle pathological narrowing and topological connectivity required to distinguish hypertensive from normotensive eyes. Results show that MARVEL significantly improves the classification of hypertension via arteriovenous pressure differences in the eye (p < 0.001), outperforming baseline models in both topological consistency and clinical predictive value.

Towards Clinically Interpretable Ophthalmic VQA via Spatially-Grounded Lesion Evidence

Visual Question Answering (VQA) holds great promise for clinical support, particularly in ophthalmology, where retinal fundus photography is essential for diagnosis. However, ophthalmic VQA benchmarks primarily emphasize answer accuracy, neglecting the explicit visual evidence necessary for clinical interpretability. In this work, we introduce FundusGround, a new benchmark for clinically interpretable ophthalmic VQA with spatially-grounded lesion evidence. Specifically, we propose a three-stage pipeline that collects 10,719 fundus images with 15,595 image-level meticulously annotated lesions. To ensure anatomical consistency and clinical validity, all lesions are spatially localized using the Early Treatment Diabetic Retinopathy Study (ETDRS) grid, enabling standardized mapping to nine clinically meaningful retinal regions. Built upon this structured lesion evidence, 72,706 questions are then generated spanning four formats: open-ended, closed-ended, single-choice, and multiple-choice. We further benchmark multiple general- and medical- large vision-language models using dual metrics for answer accuracy and lesion-level reasoning. The experiments demonstrate that incorporating lesion-level visual evidence consistently improves model performance and transparency, highlighting the necessity of explicit spatial grounding for reliable and explainable ophthalmic VQA.

MFVLR: Multi-domain Fine-grained Vision-Language Reconstruction for Generalizable Diffusion Face Forgery Detection and Localization

The swift advancement in photo-realistic face generation technology has sparked considerable concerns across society and academia, emphasizing the requirement of generalizable face forgery detection and localization methods. Prior works tend to capture face forgery patterns across multiple domains using image modality, other modalities like fine-grained texts are not comprehensively investigated, which restricts the generalization capability of models. Besides, they usually analyze facial images created by GAN, but struggle to identify and localize those synthesized by diffusion. To solve the problems, in this paper, we devise a novel multi-domain fine-grained vision-language reconstruction (MFVLR) model, which explores comprehensive and diverse visual forgery traces via language-guided face forgery representation learning, to achieve generalizable diffusion-synthesized face forgery detection and localization (DFFDL). Specifically, we devise a fine-grained language transformer that studies general fine-grained language embeddings using language reconstruction. We propose a multi-domain vision encoder to capture general and complementary visual forgery patterns across the image and residual domains. A vision decoder is designed to reconstruct image appearance and achieve forgery localization. Besides, we propose an innovative plug-and-play vision injection module to enhance the interaction between the vision and language embeddings. Extensive experiments and visualizations demonstrate that our network outperforms the state of the art on different settings like cross-generator, cross-forgery, and cross-dataset evaluations.

Think, then Score: Decoupled Reasoning and Scoring for Video Reward Modeling

Recent advances in generative video models are increasingly driven by post-training and test-time scaling, both of which critically depend on the quality of video reward models (RMs). An ideal reward model should predict accurate rewards that align with human preferences across diverse scenarios. However, existing paradigms face a fundamental dilemma: \textit{Discriminative RMs} regress rewards directly on features extracted by multimodal large language models (MLLMs) without explicit reasoning, making them prone to shortcut learning and heavily reliant on massive data scaling for generalization. In contrast, \textit{Generative RMs} with Chain-of-Thought (CoT) reasoning exhibit superior interpretability and generalization potential, as they leverage fine-grained semantic supervision to internalize the rationales behind human preferences. However, they suffer from inherent optimization bottlenecks due to the coupling of reasoning and scoring within a single autoregressive inference chain. To harness the generalization benefits of CoT reasoning while mitigating the training instability of coupled reasoning and scoring, we introduce DeScore, a training-efficient and generalizable video reward model. DeScore employs a decoupled ``think-then-score'' paradigm: an MLLM first generates an explicit CoT, followed by a dedicated discriminative scoring module consisting of a learnable query token and a regression head that predicts the final reward. DeScore is optimized via a two-stage framework: (1) a discriminative cold start incorporating a random mask mechanism to ensure robust scoring capabilities, and (2) a dual-objective reinforcement learning stage that independently refines CoT reasoning quality and calibrates the final reward, ensuring that higher-quality reasoning directly translates to superior model performance.

Resolving the bias-precision paradox with stochastic causal representation learning for personalized medicine

Estimating individualized treatment effects from longitudinal observational data is central to data-driven medicine, yet existing methods face a fundamental limitation: reducing confounding bias often suppresses clinically informative heterogeneity, degrading patient-specific predictions. Here, we identify this tension as a bias-precision paradox in causal representation learning and introduce sampling-based maximum mean discrepancy (sMMD), a stochastic alignment strategy that replaces global adversarial balancing with subset-level matching. We instantiate this approach in a framework for counterfactual outcome prediction with attribution-grounded interpretability. Across two large-scale ICU cohorts (n = 27,783), our framework improves accuracy under distribution shift, reducing error by up to 11.5% and substantially increasing recall in high-risk tasks. Mechanistic analyses show that sMMD selectively preserves clinically decisive variables. In human-AI evaluation, our method outperforms clinicians-in-training and large language models, and improves clinician accuracy by 14.7% while reducing decision time, enabling interpretable, real-time clinical decision support.

Omni-o3: Deep Nested Omnimodal Deduction for Deliberative Audio-Visual Reasoning

Omnimodal understanding entails a massive, highly redundant search space of cross-modal interactions, demanding focused and deliberative reasoning. Current reasoning paradigms rely on either sequential step-by-step generation or parallel sample-by-sample rollouts, leading to isolated reasoning trajectories. This inability to share promising intermediate paths severely limits exploration efficiency and causes compounding errors in complex audio-visual tasks. To break this bottleneck, we introduce Omni-o3, a novel framework driven by a deep nested deduction policy. By formulating reasoning as a dynamic recursive search, Omni-o3 inherently shares reasoning prefixes across branches, enabling the iterative execution of four atomic cognitive actions: expansion, selection, simulation, and backpropagation. To empower this framework, we propose a robust two-stage training paradigm: (1) cold-start supervised fine-tuning on 101K high-quality, long-chain trajectories distilled from 3.5M diverse omnimodal samples, enabling necessary recursive search patterns; and (2) nested group rollout-driven exploratory reinforcement learning on 18K complex multi-turn samples, explicitly guided by a novel multi-step reward model to stimulate deep nested reasoning. Extensive experiments demonstrate that Omni-o3 achieves competitive performance across 11 benchmarks, unlocking advanced capabilities in comprehensive audio-visual, visual-centric, and audio-centric reasoning tasks.

Understanding and Mitigating Spurious Signal Amplification in Test-Time Reinforcement Learning for Math Reasoning

Test-time reinforcement learning (TTRL) always adapts models at inference time via pseudo-labeling, leaving it vulnerable to spurious optimization signals from label noise. Through an empirical study, we observe that responses with medium consistency form an ambiguity region and constitute the primary source of reward noise. Crucially, we find that such spurious signals can be even amplified through group-relative advantage estimation. Motivated by these findings, we propose a unified framework, Debiased and Denoised test-time Reinforcement Learning (DDRL), to mitigate spurious signals. Concretely, DDRL first applies a frequency-based sampling strategy to exclude ambiguous samples while maintaining a balanced set of positive and negative examples. It then adopts a debiased advantage estimation with fixed advantages, removing the bias introduced by group-relative policy optimization. Finally, DDRL incorporates a consensus-based off-policy refinement stage, which leverages the rejection-sampled dataset to enable efficient and stable model updates. Experiments on three large language models across multiple mathematical reasoning benchmarks demonstrate that DDRL consistently outperforms existing TTRL baselines. The code will soon be released at https://github.com/yuyongcan/DDRL.

WebUncertainty: Dual-Level Uncertainty Driven Planning and Reasoning For Autonomous Web Agent

Recent advancements in large language models (LLMs) have empowered autonomous web agents to execute natural language instructions directly on real-world webpages. However, existing agents often struggle with complex tasks involving dynamic interactions and long-horizon execution due to rigid planning strategies and hallucination-prone reasoning. To address these limitations, we propose WebUncertainty, a novel autonomous agent framework designed to tackle dual-level uncertainty in planning and reasoning. Specifically, we design a Task Uncertainty-Driven Adaptive Planning Mechanism that adaptively selects planning modes to navigate unknown environments. Furthermore, we introduce an Action Uncertainty-Driven Monte Carlo tree search (MCTS) Reasoning Mechanism. This mechanism incorporates the Confidence-induced Action Uncertainty (ConActU) strategy to quantify both aleatoric uncertainty (AU) and epistemic uncertainty (EU), thereby optimizing the search process and guiding robust decision-making. Experimental results on the WebArena and WebVoyager benchmarks demonstrate that WebUncertainty achieves superior performance compared to state-of-the-art baselines.